Tumor Necrosis Factor-α Inhibits Surfactant Protein C Gene Transcription

Tumor necrosis factor-alpha inhibits expression of pulmonary surfactant protein.

Tumor necrosis factor-alpha (TNF-alpha) decreased the expression of pulmonary surfactant proteins SP-A and SP-B in human pulmonary adenocarcinoma cell lines. The effect of TNF alpha on SP-A content and mRNA in the pulmonary adenocarcinoma cell line, H441-4, was concentration and time dependent. TNF alpha decreased the cellular content of SP-A to less than 10% of control 48 h after addition. TNF...

Tumor necrosis factor- inhibits renin gene expression

Todorov, Vladimir, Markus Müller, Frank Schweda, and Armin Kurtz. Tumor necrosis factorinhibits renin gene expression. Am J Physiol Regul Integr Comp Physiol 283: R1046–R1051, 2002. First published June 27, 2002; 10.1152/ajpregu.00142.2002.—Renin, produced in renal juxtaglomerular (JG) cells, is a fundamental regulator of blood pressure. Accumulating evidence suggests that cytokines may directl...

Erythromycin Inhibits Tumor Necrosis Factor

Interactive effect of aerobic exercise with Saffron extract on serum, tumor necrosis factor-α and C-reactive protein in rats following an aerobic exercise until exhaustion

Objective: Aerobic training and Saffron has beneficial effects on inflammatory response. The present study aims to investigate the Interactive effect of aerobic training with Saffron extract on serum, tumor necrosis factor-α and C-reactive protein in rats following an aerobic exercise until exhaustion .Methods: This is a clinical trial, 48 Wistar male rats were assigned into following four grou...

Effects of Inflammatory Cytokine Tumor Necrosis Factor-α on Human Mesenchymal Stem Cell Gene Expression: A Mechanism for Liver Regeneration

Introduction  Insulin-like growth factor I (IGF-I) which is produced in abundance in the normal adult liver, is deeply involved in hepatocyte survival, growth, and differentiation during liver development. IGF-I plays the roles via the receptor (IGF-IR) signaling pathway. IGF-IR unlike IGF-I is expressed strongly in the developing liver, but much more weakly in adults. Objective:  We hypothesi...